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Activation-Induced Deaminase: On the Targeting Mechanism of - download pdf or read online

By Andrew Franklin

ISBN-10: 3110459957

ISBN-13: 9783110459951

During the process the immune reaction, antigen-activated B cells produce antibodies with elevated affinity for the antigen, a approach known as affinity maturation. a number produces antibodies with successively better affinities with repeated publicity to a similar antigen, that's the main wherein so much vaccines work.
Affinity maturation is dependent upon hypermutation, an iterative technique of mutation at antibody-encoding genes, by way of optimistic collection of B cells expressing antibodies with elevated affinity. The mechanism of hypermutation is taken into account to be one of many final nice mysteries in molecular biology. Mutation can result in genomic instability, so how are mutations selectively brought to antibody-encoding genes in activated B cells?
A significant leap forward got here in 2000 with the invention that activation-induced deaminase (AID) is admittedly required for hypermutation. This was once in 2002 by means of facts that relief at once edits the DNA that encodes an antibody in an activated B telephone. a lot has for the reason that been learnt in regards to the biochemistry and legislation of reduction, however the mechanism in which it truly is recruited in particular to antibody-encoding genes continues to be enigmatic. figuring out this recruitment is clinically major simply because off-target relief task at oncogenes may end up in chromosomal translocations and tumorigenesis.
This ebook summarizes the examine on relief within the context of its vital function within the affinity maturation of B cells.

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Activation-Induced Deaminase: On the Targeting Mechanism of AID to the Immunoglobulin Loci by Andrew Franklin


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